DNA Origami Nanoscale Breadboards for Carbon Nanotube Circuits


Hareem T. Maune, a graduate student studying carbon nanotube physics, and Si-ping Han, a graduate student investigating the interactions between carbon nanotubes and DNA have developed DNA origami nanoscale breadboards for carbon nanotube circuits. "This collaborative research project is evidence of how we at Caltech select the top students in science and engineering and place them in an environment where their creativity and imagination can thrive," says Ares Rosakis, chair of the Division of Engineering and Applied Science at Caltech and Theodore von Kármán Professor of Aeronautics and Professor of Mechanical Engineering. The work of these students was supervised by: Erik Winfree, Associate Professor of Computer Science, Computation and Neural Systems, and Bioengineering; William A. Goddard III, Charles and Mary Ferkel Professor of Chemistry, Materials Science, and Applied Physics; Paul W.K. Rothemund, Senior Research Associate, and Marc Bockrath, Associate Professor of Physics at University of California Riverside. [Caltech Press Release]

Tags: APhMS research highlights CMS Erik Winfree William Goddard Paul Rothemund Si-ping Han

Erik Winfree Featured in Discover


The molecular computational research of Erik Winfree, Associate Professor of Computer Science, Computation and Neural Systems, and Bioengineering, focuses on understanding how chemical systems can perform information processing and how to program a set of molecules to carry out instructions. This exciting research was recently featured in Discover. [Discover Interview]

Tags: EE research highlights CMS Erik Winfree

Erik Winfree Controls Complex Nucleation Processes using DNA Origami Seeds


"Flowers, dogs, and just about all biological objects are created from the bottom up," says Erik Winfree, associate professor of computer science, computation and neural systems, and bioengineering at Caltech. Along with his coworkers, Winfree is seeking to integrate bottom-up construction approaches with molecular fabrication processes to construct objects from parts that are just a few billionths of a meter in size that essentially assemble themselves. In a recent paper in the Proceedings of the National Academy of Sciences (PNAS), Winfree and his colleagues describe the development of an information-containing DNA "seed" that can direct the self-assembled bottom-up growth of tiles of DNA in a precisely controlled fashion. In some ways, the process is similar to how the fertilized seeds of plants or animals contain information that directs the growth and development of those organisms. [Caltech Press Release]

Tags: research highlights health CMS Erik Winfree

$10 Million Awarded to the Molecular Programming Project Led by Erik Winfree


The National Science Foundation's Expeditions in Computing program has awarded $10 million to the Molecular Programming Project, a collaborative effort by researchers at Caltech and the University of Washington, led by Professor Erik Winfree, to establish a fundamental approach to the design of complex molecular and chemical systems based on the principles of computer science. [Caltech Press Release]

Tags: research highlights CMS Erik Winfree