Paul Rothemund and Colleagues Use Self-Assembled DNA Scaffolding to Build Tiny Circuit Boards


Dr. Paul Rothemund, Senior Research Associate in Bioengineering, Computer Science, and Computation and Neural Systems, and colleagues have developed a new technique to orient and position self-assembled DNA shapes and patterns--or "DNA origami"--on surfaces that are compatible with today's semiconductor manufacturing equipment. They "have removed a key barrier to the improvement and advancement of computer chips. They accomplished this through the revolutionary approach of combining the building blocks for life with the building blocks for computing," said Professor Ares Rosakis, Chair of Division of Engineering and Applied Science and Theodore von Kármán Professor of Aeronautics and Mechanical Engineering. [Caltech Press Release]

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John Doyle Discovers the Importance of Fire in Global Climate Change


Scientists Discover Importance of Fire in Global Climate Change. Researchers including John Doyle, Caltech's Braun Professor of Control and Dynamical Systems, Electrical Engineering, and Bioengineering, Emeritus, have determined that fire must be accounted for as an integral part of climate change. Their research shows that intentional deforestation fires alone contribute up to one-fifth of the human-caused increase in emissions of carbon dioxide. According to the article, increasing numbers of natural wildfires are influencing climate as well. [Science Magazine article]

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Erik Winfree Controls Complex Nucleation Processes using DNA Origami Seeds


"Flowers, dogs, and just about all biological objects are created from the bottom up," says Erik Winfree, associate professor of computer science, computation and neural systems, and bioengineering at Caltech. Along with his coworkers, Winfree is seeking to integrate bottom-up construction approaches with molecular fabrication processes to construct objects from parts that are just a few billionths of a meter in size that essentially assemble themselves. In a recent paper in the Proceedings of the National Academy of Sciences (PNAS), Winfree and his colleagues describe the development of an information-containing DNA "seed" that can direct the self-assembled bottom-up growth of tiles of DNA in a precisely controlled fashion. In some ways, the process is similar to how the fertilized seeds of plants or animals contain information that directs the growth and development of those organisms. [Caltech Press Release]

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Niles Pierce and Michael Elowitz on Nature List of Favourite Articles


The editors of Nature have published a list of 22 of their favourite articles from 2008 - including Programming biomolecular self-assembly pathways by Niles Pierce, Associate Professor of Applied and Computational Mathematics and Bioengineering, and colleagues, and Frequency-modulated nuclear localization bursts coordinate gene regulation by Michael Elowitz, Assistant Professor of Biology and Applied Physics and Bren Scholar, and colleagues. 

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$10 Million Awarded to the Molecular Programming Project Led by Erik Winfree


The National Science Foundation's Expeditions in Computing program has awarded $10 million to the Molecular Programming Project, a collaborative effort by researchers at Caltech and the University of Washington, led by Professor Erik Winfree, to establish a fundamental approach to the design of complex molecular and chemical systems based on the principles of computer science. [Caltech Press Release]

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Emmanuel Candes Receives Information Theory Society Paper Award


Emmanuel Candes, Ronald and Maxine Linde Professor of Applied and Computational Mathematics, has garnered the 2008 Information Theory Society Paper Award jointly with Terence Tao and David Donoho. Their ground-breaking papers were cited for independently introducing the new area of compressed sensing, which holds great promise for processing massive amounts of data, and has already had a broad impact on a diverse set of fields, including signal processing, information theory, function approximation, MRI, and radar design.

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Steven Low and Team Reach New Records for Sustained Data Transfer Among Storage Systems


Building on six years of record-breaking developments, an international team of physicists, computer scientists, and network engineers led by Caltech joined forces to set new records for sustained data transfer among storage systems during the SuperComputing 2007 (SC07) conference. By combining FDT with FAST TCP, developed by Professor Steven Low, together with an optimized Linux kernel known as the "UltraLight kernel," the team reached an unprecedented throughput level of 10 gigabytes/sec with a single rack of servers, limited only by the speed of the disk systems. [Caltech Press Release]

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