CNS Seminar/ Cornelis Wiersma Visiting Professor Lecture

Monday September 26, 2016 4:00 PM

"Probing Neural Circuits with Shaped Light"

Speaker: Na Ji, Janelia Research Campus, Janelia Research Campus, Ashburn, Virgina
Location: Beckman Behavioral Biology B180

Abstract: To understand computation in the brain, one needs to understand the input-output relationships for neural circuits and the anatomical and functional relationships between individual neurons therein. Optical microscopy has emerged as an ideal tool in this quest, as it is capable of recording the activity of neurons distributed over millimeter dimensions with sub-micron spatial resolution. I will describe how we use advanced microscopy methods to image neural circuits at higher resolution, greater depth, and faster speed. By shaping the wavefront of the light, we have achieved synapse-level spatial resolution through the entire depth of primary visual cortex, optimized microendoscopes for imaging deeply buried nuclei, and developed a video-rate (30 Hz) volumetric imaging method. We apply these methods to understanding neural circuits, using the mouse primary visual cortex as our model system.
 

Series Wiersma Lecture

Contact: Linda Scott at ext. 4389 scottl@caltech.edu