Computer Science Seminar
How local is the local field potential?
In the seminar I will present new results from our group where we have used a biophysical forward-modelling approach (Holt and Koch, J Comp Neurosci, 1999) to address this question (Linden et al., Neuron, 2011). Specifically, we have calculated the LFP signal from synaptically activated populations of morphologically reconstructed cortical cells and investigated how various key factors determine the size of the region that an LFP electrode can 'see', in particular, the neuronal morphology, distribution of synapses, level of correlation in synaptic activity, and the position of the recording electrode. I will further present results for how steeply the LFP signal decays outside an active population and finally suggest some simple rules-of-thumb-answers to the question raised in the title.
Contact: Tanya Owen at 626-395-8817 email@example.com